February 18, 2022

Orioles  sign Shed Long

March 12, 2022

Orioles  sign Jordan Lyles as a free agent

March 13, 2022

Orioles  sign Anthony Bemboom

March 14, 2022

Orioles  sign Robinson Chirinos as a free agent

March 15, 2022

Orioles  sign Chris Owings

March 16, 2022

Orioles  sign Chris Ellis

Orioles  sign Conner Greene

April 03, 2022

April 08, 2022

Orioles  sign Matt Harvey

April 11, 2022

Orioles  place Dean Kremer on the injured list

Orioles  place Spenser Watkins on the injured list

April 14, 2022

Orioles  place John Means on the injured list

April 15, 2022

Orioles  place John Means on the injured list

April 19, 2022

Orioles  designate DJ Stewart for assignment

April 26, 2022

Orioles  place Chris Ellis on the injured list

May 02, 2022

Orioles  designate Kelvin Gutierrez for assignment

May 13, 2022

Orioles  place Ryan Mountcastle on the injured list

May 14, 2022

Orioles  designate Paul Fry for assignment

May 17, 2022

Orioles  designate Logan Allen for assignment

May 18, 2022

Paul Fry traded from Orioles  to Diamondbacks 

May 20, 2022

Orioles  place Travis Lakins on the injured list

May 21, 2022

Orioles  designate Anthony Bemboom for assignment

May 28, 2022

Orioles  designate Jahmai Jones for assignment

June 03, 2022

Orioles  place Joey Krehbiel on the injured list

Orioles  release Jahmai Jones

June 07, 2022

Orioles  designate Cody Sedlock for assignment

June 08, 2022

Orioles  designate Chris Owings for assignment

June 10, 2022

Orioles  place Ramon Urias on the injured list

June 12, 2022

Orioles  release Chris Owings

June 15, 2022

Orioles  designate Zac Lowther for assignment

June 24, 2022

Orioles  place Kyle Bradish on the injured list

July 06, 2022

Orioles  designate Marcos Diplan for assignment

July 11, 2022

Cody Sedlock traded from Orioles  to Tigers 

July 12, 2022

Orioles  designate Kirk McCarty for assignment

July 26, 2022

Orioles  place Jonathan Arauz on the injured list

July 28, 2022

Orioles  place Tyler Wells on the injured list

August 01, 2022

Trey Mancini traded from Orioles  to Astros 

August 02, 2022

Brett Phillips traded from Rays  to Orioles 

August 19, 2022

Orioles  designate Brett Phillips for assignment

August 31, 2022

Orioles  designate Denyi Reyes for assignment

Orioles  sign Jesus Aguilar

September 01, 2022

Orioles  designate Richie Martin for assignment

September 03, 2022

Orioles  designate Phoenix Sanders for assignment

September 06, 2022

Orioles  designate Jonathan Arauz for assignment

September 11, 2022

Orioles  designate Rico Garcia for assignment

September 23, 2022

Orioles  place Tyler Wells on the injured list

September 28, 2022

Orioles  place Ramon Urias on the injured list

October 03, 2022

Orioles  place Felix Bautista on the injured list

October 06, 2022

Orioles  designate Anthony Castro for assignment

October 11, 2022

Orioles  designate Jake Reed for assignment

October 14, 2022

Orioles  designate Louis Head for assignment

Orioles  designate Beau Sulser for assignment

November 06, 2022

Robinson Chirinos became a free agent

Rougned Odor became a free agent

Jesus Aguilar became a free agent

November 09, 2022

Jordan Lyles became a free agent

December 02, 2022

Orioles  sign Franchy Cordero as a free agent

December 03, 2022

Orioles  sign Kyle Gibson as a free agent