January 24, 2022

Cubs  sign Eric Yardley

January 31, 2022

Cubs  sign John Hicks

February 08, 2022

Cubs  sign Matt Dermody

March 14, 2022

Cubs  sign Jesse Chavez

March 15, 2022

Cubs  sign Andrelton Simmons as a free agent

March 16, 2022

Cubs  place Codi Heuer on the injured list

Cubs  sign Eric Stout

Cubs  sign David Robertson as a free agent

March 17, 2022

Cubs  place Brad Wieck on the injured list

Cubs  sign Chris Martin as a free agent

March 18, 2022

Cubs  place Adbert Alzolay on the injured list

Cubs  sign Seiya Suzuki as a free agent

March 19, 2022

Cubs  place Tommy Nance on the injured list

Cubs  place David Bote on the injured list

Cubs  sign Adrian Sampson

Cubs  sign Jonathan Villar as a free agent

Cubs  sign Drew Smyly as a free agent

Cubs  sign Daniel Norris as a free agent

March 20, 2022

Cubs  sign Robel Garcia

March 21, 2022

Cubs  sign Robert Gsellman

March 22, 2022

Cubs  sign Steven Brault

March 23, 2022

Cubs  designate Sergio Alcantara for assignment

Cubs  sign Mychal Givens as a free agent

March 25, 2022

Cubs  designate Tommy Nance for assignment

March 27, 2022

Sergio Alcantara traded from Cubs  to Diamondbacks 

April 04, 2022

Cubs  place Andrelton Simmons on the injured list

Cubs  place Alec Mills on the injured list

Cubs  place Wade Miley on the injured list

April 16, 2022

Cubs  designate Cory Abbott for assignment

Cubs  designate Greg Deichmann for assignment

April 17, 2022

Cubs  place Keegan Thompson on the injured list

April 21, 2022

Cory Abbott traded from Cubs  to Giants 

April 22, 2022

Cubs  place Clint Frazier on the injured list

May 02, 2022

Cubs  place Ethan Roberts on the injured list

May 03, 2022

Cubs  designate Locke St. John for assignment

May 08, 2022

Cubs  place Marcus Stroman on the injured list

Cubs  place Michael Hermosillo on the injured list

Cubs  sign Luke Farrell

May 09, 2022

Cubs  place David Robertson on the injured list

Cubs  place Frank Schwindel on the injured list

May 10, 2022

Cubs  place Nick Madrigal on the injured list

Cubs  place Wade Miley on the injured list

Cubs  designate Adrian Sampson for assignment

May 11, 2022

Cubs  place Sean Newcomb on the injured list

May 15, 2022

Cubs  place Nico Hoerner on the injured list

May 17, 2022

Cubs  place Jason Heyward on the injured list

May 19, 2022

Cubs  place Michael Rucker on the injured list

Cubs  place Alec Mills on the injured list

May 22, 2022

Cubs  designate Ildemaro Vargas for assignment

May 25, 2022

Cubs  place Yan Gomes on the injured list

May 26, 2022

Ildemaro Vargas became a free agent

May 27, 2022

Cubs  place Seiya Suzuki on the injured list

May 30, 2022

Cubs  place Jonathan Villar on the injured list

Cubs  designate Robert Gsellman for assignment

May 31, 2022

Cubs  sign Adrian Sampson

June 01, 2022

Cubs  place Manuel Rodriguez on the injured list

Cubs  place Drew Smyly on the injured list

June 04, 2022

Cubs  designate Conner Menez for assignment

June 10, 2022

Cubs  designate Clint Frazier for assignment

Cubs  place Marcus Stroman on the injured list

June 13, 2022

Cubs  designate Sean Newcomb for assignment

June 15, 2022

Cubs  place Nick Madrigal on the injured list

June 16, 2022

Cubs  designate Eric Stout for assignment

June 18, 2022

Cubs  place Frank Schwindel on the injured list

June 21, 2022

Eric Stout traded from Cubs  to Pirates 

June 23, 2022

Cubs  place Daniel Norris on the injured list

June 24, 2022

Cubs  designate Jonathan Villar for assignment

June 28, 2022

Cubs  release Jonathan Villar

June 30, 2022

Cubs  place Jason Heyward on the injured list

July 03, 2022

Cubs  place Alec Mills on the injured list

July 06, 2022

Cubs  place Kyle Hendricks on the injured list

July 14, 2022

Cubs  place Andrelton Simmons on the injured list

July 16, 2022

Cubs  designate Matt Swarmer for assignment

July 17, 2022

Cubs  designate Daniel Norris for assignment

July 22, 2022

Cubs  release Daniel Norris

July 30, 2022

July 31, 2022

August 01, 2022

August 02, 2022

Cubs  place Steven Brault on the injured list

Cubs  place Nick Madrigal on the injured list

Mychal Givens traded from Cubs  to Mets 

David Robertson traded from Cubs  to Phillies 

August 06, 2022

Cubs  designate Andrelton Simmons for assignment

August 07, 2022

Cubs  release Andrelton Simmons

August 24, 2022

Cubs  place Steven Brault on the injured list

August 27, 2022

Cubs  place Patrick Wisdom on the injured list

September 01, 2022

Cubs  place Wade Miley on the injured list

September 05, 2022

Cubs  place Justin Steele on the injured list

Cubs  designate Kervin Castro for assignment

September 06, 2022

Cubs  place Willson Contreras on the injured list

Cubs  designate Nicholas Padilla for assignment

Cubs  designate Luke Farrell for assignment

September 14, 2022

Cubs  place Rafael Ortega on the injured list

September 17, 2022

Cubs  designate Frank Schwindel for assignment

Cubs  designate Sean Newcomb for assignment

September 18, 2022

Cubs  release Frank Schwindel

September 27, 2022

Cubs  designate Michael Hermosillo for assignment

November 06, 2022

Wade Miley became a free agent

Willson Contreras became a free agent

November 09, 2022

Drew Smyly became a free agent

November 14, 2022

Cubs  release Jason Heyward

November 15, 2022

Miles Mastrobuoni traded from Rays  to Cubs 

November 18, 2022

Rafael Ortega became a free agent

December 09, 2022

Cubs  sign Eric Stout as a free agent