January 27, 2022

Cardinals  sign Aaron Brooks

March 11, 2022

Cardinals  sign Drew VerHagen as a free agent

March 13, 2022

Cardinals  sign Nick Wittgren as a free agent

March 18, 2022

Cardinals  sign Corey Dickerson as a free agent

March 25, 2022

Cardinals  sign Cory Spangenberg

March 26, 2022

Cardinals  sign Blake Parker

March 28, 2022

Cardinals  sign Albert Pujols as a free agent

March 30, 2022

Cardinals  release Jesus Cruz

April 04, 2022

Cardinals  place Jack Flaherty on the injured list

Cardinals  release Anderson Tejeda

April 22, 2022

Cardinals  place Drew VerHagen on the injured list

May 02, 2022

Cardinals  designate Aaron Brooks for assignment

May 03, 2022

Cardinals  place Edmundo Sosa on the injured list

May 06, 2022

Cardinals  place Adam Wainwright on the injured list

May 20, 2022

Cardinals  place Tyler O'Neill on the injured list

May 21, 2022

Cardinals  designate T.J. Zeuch for assignment

May 23, 2022

Cardinals  place Steven Matz on the injured list

Cardinals  place Dylan Carlson on the injured list

May 26, 2022

Cardinals  place Jordan Hicks on the injured list

Cardinals  release T.J. Zeuch

June 03, 2022

Cardinals  designate Kramer Robertson for assignment

June 05, 2022

Cardinals  place Corey Dickerson on the injured list

June 15, 2022

Cardinals  designate Ali Sanchez for assignment

June 17, 2022

Cardinals  place Yadier Molina on the injured list

June 20, 2022

Cardinals  place Tyler O'Neill on the injured list

June 22, 2022

Cardinals  place T.J. McFarland on the injured list

June 24, 2022

Cardinals  place Drew VerHagen on the injured list

June 25, 2022

Cardinals  place Genesis Cabrera on the injured list

June 27, 2022

Cardinals  place Jack Flaherty on the injured list

Cardinals  place Harrison Bader on the injured list

July 02, 2022

Cardinals  designate Nick Wittgren for assignment

July 08, 2022

Cardinals  designate Angel Rondon for assignment

July 09, 2022

Cardinals  release Nick Wittgren

July 15, 2022

Cardinals  place Dakota Hudson on the injured list

Cardinals  place Juan Yepez on the injured list

July 17, 2022

Cardinals  place Drew VerHagen on the injured list

July 30, 2022

August 01, 2022

August 02, 2022

Austin Romine traded from Cardinals  to Reds 

Austin Allen traded from Athletics  to Cardinals 

August 10, 2022

Cardinals  designate T.J. McFarland for assignment

August 12, 2022

Cardinals  release T.J. McFarland

August 23, 2022

Cardinals  sign T.J. McFarland

September 05, 2022

Cardinals  designate Junior Fernandez for assignment

September 07, 2022

Cardinals  place Dylan Carlson on the injured list

Cardinals  designate Conner Capel for assignment

September 17, 2022

Cardinals  place Tyler O'Neill on the injured list

Cardinals  place Jordan Hicks on the injured list

November 01, 2022

Yadier Molina retired

Albert Pujols retired

November 06, 2022

Corey Dickerson became a free agent

Jose Quintana became a free agent

November 18, 2022

Ben DeLuzio became a free agent

Alex Reyes became a free agent

Cardinals  sign Oscar Mercado

Cardinals  sign Taylor Motter