January 29, 2021

Cardinals  sign Adam Wainwright as a free agent

February 01, 2021

February 04, 2021

Dexter Fowler traded from Cardinals  to Angels 

February 09, 2021

Cardinals  sign Yadier Molina as a free agent

February 12, 2021

Ali Sanchez traded from Mets  to Cardinals 

April 01, 2021

Cardinals  place Dakota Hudson on the injured list

Cardinals  place Miles Mikolas on the injured list

Cardinals  place Harrison Bader on the injured list

Cardinals  place Kwang Hyun Kim on the injured list

April 11, 2021

Cardinals  place Tyler O'Neill on the injured list

April 15, 2021

Cardinals  place Dakota Hudson on the injured list

April 23, 2021

Cardinals  place John Nogowski on the injured list

April 27, 2021

Cardinals  place Yadier Molina on the injured list

April 30, 2021

Cardinals  place Andrew Miller on the injured list

Cardinals  place Daniel Ponce de Leon on the injured list

Cardinals  place Adam Wainwright on the injured list

May 04, 2021

Cardinals  place Jordan Hicks on the injured list

May 11, 2021

Cardinals  place Carlos Martinez on the injured list

May 14, 2021

Cardinals  place Paul DeJong on the injured list

Cardinals  place Jordan Hicks on the injured list

May 18, 2021

Cardinals  place Tyler O'Neill on the injured list

May 23, 2021

Cardinals  place Miles Mikolas on the injured list

May 25, 2021

Cardinals  place Harrison Bader on the injured list

May 29, 2021

Cardinals  place Max Moroff on the injured list

Cardinals  place Miles Mikolas on the injured list

May 30, 2021

Cardinals  place Kodi Whitley on the injured list

June 01, 2021

Cardinals  place Jack Flaherty on the injured list

June 03, 2021

Cardinals  designate Tyler Webb for assignment

June 05, 2021

Cardinals  place Justin Williams on the injured list

Cardinals  place Kwang Hyun Kim on the injured list

June 14, 2021

Cardinals  sign Brandon Dickson

June 17, 2021

Cardinals  place Max Moroff on the injured list

Cardinals  sign Wade LeBlanc as a free agent

June 22, 2021

Cardinals  designate Bernardo Flores for assignment

June 23, 2021

Cardinals  place Daniel Ponce de Leon on the injured list

June 28, 2021

Cardinals  designate John Nogowski for assignment

July 01, 2021

Cardinals  sign T.J. McFarland

July 02, 2021

Cardinals  place Jack Flaherty on the injured list

July 03, 2021

John Nogowski traded from Cardinals  to Pirates 

July 07, 2021

Cardinals  place Carlos Martinez on the injured list

July 09, 2021

Cardinals  place Carlos Martinez on the injured list

Cardinals  sign Luis Garcia as a free agent

July 25, 2021

T.J. Zeuch traded from Blue Jays  to Cardinals 

July 30, 2021

August 09, 2021

Cardinals  place Kwang Hyun Kim on the injured list

August 13, 2021

Cardinals  place Wade LeBlanc on the injured list

August 14, 2021

Cardinals  designate Scott Hurst for assignment

August 17, 2021

Cardinals  place Dylan Carlson on the injured list

August 18, 2021

Cardinals  place Justin Miller on the injured list

August 20, 2021

Cardinals  place Ryan Helsley on the injured list

August 25, 2021

Cardinals  place Jack Flaherty on the injured list

August 28, 2021

Cardinals  place Andrew Miller on the injured list

September 01, 2021

Cardinals  place Ryan Helsley on the injured list

September 03, 2021

Cardinals  place Junior Fernandez on the injured list

September 06, 2021

Cardinals  designate Brandon Dickson for assignment

September 12, 2021

Cardinals  place Junior Fernandez on the injured list

September 20, 2021

Cardinals  designate Daniel Ponce de Leon for assignment

September 25, 2021

Cardinals  place Justin Miller on the injured list

October 06, 2021

Cardinals  designate Seth Elledge for assignment

October 25, 2021

Cardinals  designate Justin Miller for assignment

November 03, 2021

Wade LeBlanc became a free agent

J.A. Happ became a free agent

Luis Garcia became a free agent

T.J. McFarland became a free agent

Jon Lester became a free agent

Andrew Miller became a free agent

Kwang Hyun Kim became a free agent

November 04, 2021

Matt Carpenter became a free agent

Carlos Martinez became a free agent

November 08, 2021

Cardinals  sign T.J. McFarland as a free agent

November 09, 2021

Cardinals  sign Anderson Tejeda

November 29, 2021

Cardinals  sign Steven Matz as a free agent

November 30, 2021

Jose Rondon became a free agent