April 02, 2016
Red Sox 
place
Brandon Workman
on the injured list
Red Sox
place
Christian Vazquez
on the injured list
Red Sox
place
Eduardo Rodriguez
on the injured list
April 13, 2016
Red Sox
place
Pablo Sandoval
on the injured list
April 20, 2016
Red Sox
place
Joe Kelly
on the injured list
May 20, 2016
Red Sox
place
Brock Holt
on the injured list
June 02, 2016
Red Sox
place
Brock Holt
on the injured list
June 18, 2016
Red Sox
sign
Stephen Nogosek
July 03, 2016
Red Sox
sign
Shaun Anderson
July 07, 2016
Red Sox
designate
Ryan LaMarre
for assignment
Red Sox
sign
Santiago Espinal
July 09, 2016
Red Sox
place
Craig Kimbrel
on the injured list
July 14, 2016
Drew Pomeranz
traded from
Padres
to
Red Sox
Anderson Espinoza
traded from
Red Sox
to
Padres
July 15, 2016
Red Sox
sign
Bobby Dalbec
August 01, 2016
Fernando Abad
traded from
Twins
to
Red Sox
August 25, 2016
Red Sox
place
Andrew Benintendi
on the injured list
December 02, 2016
Bryan Holaday
became a free agent
December 06, 2016
Tyler Thornburg
traded from
Brewers
to
Red Sox
Mauricio Dubon
traded from
Red Sox
to
Brewers
Travis Shaw
traded from
Red Sox
to
Brewers
Yoan Moncada
traded from
Red Sox
to
White Sox
Chris Sale
traded from
White Sox
to
Red Sox
Michael Kopech
traded from
Red Sox
to
White Sox
December 08, 2016
Red Sox
sign
Mitch Moreland
as a free agent