January 06, 2021

Greg Allen traded from Padres  to Yankees 

January 19, 2021

January 27, 2021

Padres  sign Jurickson Profar as a free agent

February 12, 2021

Padres  sign Aaron Northcraft as a free agent

Padres  sign Miguel Diaz

February 16, 2021

Padres  sign John Andreoli

February 18, 2021

Padres  place Mike Clevinger on the injured list

Padres  sign Keone Kela as a free agent

Padres  sign Mark Melancon as a free agent

February 26, 2021

Padres  sign Patrick Kivlehan as a free agent

March 06, 2021

Padres  place Jose Castillo on the injured list

April 01, 2021

Padres  place Dan Altavilla on the injured list

Padres  place Austin Nola on the injured list

Padres  place Austin Adams on the injured list

Padres  place Michel Baez on the injured list

Padres  place Matt Strahm on the injured list

Padres  place Trent Grisham on the injured list

Padres  place Javy Guerra on the injured list

Padres  place Pierce Johnson on the injured list

Padres  place Dinelson Lamet on the injured list

April 05, 2021

Padres  place Javy Guerra on the injured list

James Norwood traded from Cubs  to Padres 

April 06, 2021

Padres  place Fernando Tatis Jr. on the injured list

April 12, 2021

Padres  place Adrian Morejon on the injured list

April 14, 2021

Padres  place Austin Adams on the injured list

Padres  place Taylor Williams on the injured list

April 17, 2021

Padres  place Matt Strahm on the injured list

Padres  place Dan Altavilla on the injured list

April 22, 2021

Padres  place Keone Kela on the injured list

Padres  place Dinelson Lamet on the injured list

April 23, 2021

Padres  place Adrian Morejon on the injured list

April 30, 2021

Padres  place Chris Paddack on the injured list

May 08, 2021

Padres  place Keone Kela on the injured list

May 11, 2021

Padres  place Fernando Tatis Jr. on the injured list

Padres  place Jorge Mateo on the injured list

Padres  place Jurickson Profar on the injured list

May 12, 2021

Padres  place Eric Hosmer on the injured list

Padres  place Wil Myers on the injured list

May 13, 2021

Padres  place Drew Pomeranz on the injured list

May 23, 2021

Padres  place Keone Kela on the injured list

May 24, 2021

Padres  place Trent Grisham on the injured list

May 28, 2021

Padres  place Dan Altavilla on the injured list

Padres  place Austin Nola on the injured list

June 05, 2021

Padres  place Taylor Williams on the injured list

June 19, 2021

Padres  place Pierce Johnson on the injured list

June 27, 2021

Padres  place Dinelson Lamet on the injured list

June 30, 2021

Padres  place Blake Snell on the injured list

July 08, 2021

Padres  place Nick Ramirez on the injured list

July 09, 2021

Padres  place Drew Pomeranz on the injured list

Padres  place Blake Snell on the injured list

Padres  designate Aaron Northcraft for assignment

July 11, 2021

Padres  place Yu Darvish on the injured list

July 13, 2021

Padres  release Aaron Northcraft

July 16, 2021

Padres  place Ryan Weathers on the injured list

July 19, 2021

Padres  sign Aaron Northcraft

July 26, 2021

July 30, 2021

July 31, 2021

Padres  place Fernando Tatis Jr. on the injured list

Padres  place Chris Paddack on the injured list

August 03, 2021

Padres  designate Jorge Mateo for assignment

August 06, 2021

Padres  place Jurickson Profar on the injured list

August 11, 2021

Padres  place Drew Pomeranz on the injured list

August 15, 2021

Padres  place Yu Darvish on the injured list

August 16, 2021

Padres  sign Jake Arrieta

August 18, 2021

Padres  place Matt Strahm on the injured list

August 20, 2021

Padres  place Drew Pomeranz on the injured list

Padres  place Jake Arrieta on the injured list

September 01, 2021

Padres  place Matt Strahm on the injured list

September 03, 2021

Padres  designate Taylor Williams for assignment

September 13, 2021

Padres  place Chris Paddack on the injured list

September 14, 2021

Padres  sign Ross Detwiler as a free agent

September 15, 2021

Padres  place Blake Snell on the injured list

Padres  sign Vince Velasquez

September 17, 2021

Padres  designate Nick Ramirez for assignment

September 21, 2021

Padres  designate Jake Arrieta for assignment

September 22, 2021

Padres  release Jake Arrieta

September 24, 2021

Padres  place Austin Nola on the injured list

September 28, 2021

Padres  place Craig Stammen on the injured list

September 30, 2021

Padres  place Yu Darvish on the injured list

October 01, 2021

Padres  place Austin Nola on the injured list

November 03, 2021

Daniel Hudson became a free agent

Ross Detwiler became a free agent

Vince Velasquez became a free agent

Tommy Pham became a free agent

November 05, 2021

Keone Kela became a free agent

Jake Marisnick became a free agent

Mark Melancon became a free agent

November 27, 2021

November 30, 2021

Matt Strahm became a free agent

Jose Castillo became a free agent

December 01, 2021

Jorge Alfaro traded from Marlins  to Padres 

Padres  sign Robert Suarez as a free agent

Padres  sign Luis Garcia as a free agent

December 14, 2021

Padres  sign Domingo Leyba